Northwestern vs. Duke Odds, Line: 2022 College Football Picks, Week 2 Predictions from Proven Computer Model

The Northwestern Wildcats will be looking to build on their season-opening win over Nebraska when they face the Duke Blue Devils on Saturday afternoon. Northwestern rallied from a 28-17 deficit, scoring 14 straight points in the 31-28 winning streak. Duke is coming off an impressive performance by knocking out Temple in a 30-0 final.

Kickoff is scheduled for noon ET. The Wildcats are favored by 9.5 points in Caesars Sportsbook’s latest Northwestern vs. Duke odds, and the over/under is set at 54. Before we get into the Duke vs. Northwestern picks, you’ll want to see the model’s college football predictions on SportsLine.

The SportsLine projection model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated an astonishing profit of nearly $3,500 for $100 players on its top-rated college football picks against the spread. He enters Week 2 of the 2022 college football season on a 48-37 run on all college football and money-line top picks that dates back to 2021. Everyone who has followed him has seen huge returns.

Now the model has set its sights on Northwestern vs. Duke. You can head to SportsLine for see their choices. Here are several college football odds for Northwestern vs. Duke:

  • Northwest Spread vs. Duke: Northwest -9.5
  • Northwestern vs. Duke over/under: 54 points
  • Northwestern pick vs. Duke: See the picks here

Featured Game | Northwestern Wildcats vs. Duke Blue Devils

Why Northwestern Can Cover

Northwestern started its first game of the season as a 12.5-point underdog against Nebraska in Ireland, but the Wildcats rallied from an 11-point deficit to claim the win. Quarterback Ryan Hilinski threw for 314 yards and two touchdowns as Northwestern finished with 528 total yards of offense. Running back Evan Hull also had a big game, rushing for 119 yards on 22 carries.

The Wildcats have a rest advantage over Duke after getting a week off between games, and they also have two prep weeks under their belt. Duke not only had to play last week, but they didn’t face the level of competition that will prepare them for this game. The Blue Devils have failed to cover in eight consecutive road games.

Why Duke can cover

Duke was just a 9.5-point favorite against Temple, which makes the 30-0 blowout very impressive. The Blue Devils recorded their first shutout victory against an FBS team since 1989 in North Carolina, as quarterback Riley Leonard threw for two touchdowns and completed his first 15 passes. Head coach Mike Elko picked up a win in his debut with the Blue Devils after serving as defensive coordinator at several other schools.

Leonard completed 24 of 30 passes for 328 yards and was the game’s leading rusher with 64 yards on 11 carries. There were a few concerns about the Blue Devils’ start to the year, but they put a lot of those concerns to rest last week. Northwestern has covered only twice in its last seven games.

How to make choices between Duke and Northwestern

The model has simulated Northwestern against Duke 10,000 times and the results are there. He looks at the total, and he’s also generated a point pick that hits in over 50% of simulations. You can only see the selection on SportsLine.

So who wins Duke vs. Northwestern? And which side of the gap hits in well over 50% of the simulations? Visit SportsLine now to find out which side of the Northwest vs. Duke spread you should jump on Saturday, all from the model who crushed his college football picksand find out.